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Structural studies on the leukocyte co-stimulatory molecule, B7-1

Abstract:

B7-1 and B7-2 are glycoproteins expressed on antigen presenting cells. The binding of these molecules to the T-cell homodimers, CD28 and CTLA-4, generate 'costimulatory' and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 Angstrom resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal lattice, ...

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Publication status:
Published

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Authors


Ikemizu, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Pages:
63-72
Publication date:
2001
URN:
uuid:c9c2eebc-338e-4576-85c9-809f0e618c46
Source identifiers:
16010
Local pid:
pubs:16010
ISBN:
4-431-70297-0

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