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Conference item

Structural studies on the leukocyte co-stimulatory molecule, B7-1

Abstract:

B7-1 and B7-2 are glycoproteins expressed on antigen presenting cells. The binding of these molecules to the T-cell homodimers, CD28 and CTLA-4, generate 'costimulatory' and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 Angstrom resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal lattice, ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
ACTIVATING AND INHIBITORY IMMUNOGLOBULIN-LIKE RECEPTORS
Pages:
63-72
Publication date:
2001-01-01
Event title:
CREST International Symposium on Immunoglobulin-like Receptors
Source identifiers:
16010
ISBN:
4431702970
Keywords:
Pubs id:
pubs:16010
UUID:
uuid:c9c2eebc-338e-4576-85c9-809f0e618c46
Local pid:
pubs:16010
Deposit date:
2012-12-19

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