Journal article
Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis
- Abstract:
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Background Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular marker of the slow clearance phenotype has been identified: single genetic changes within the propeller region of the Kelch13 protein (pfk13; Pf3D7_1343700). Global searches have identified almost 200 different non-synonymous mutant pfk13 genotypes. Most mutations occur at low prevalence and have uncertain f... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1186/s12916-018-1207-3
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Medicine Journal website
- Volume:
- 1
- Issue:
- 17
- Publication date:
- 2019-01-17
- Acceptance date:
- 2018-11-01
- DOI:
- EISSN:
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1741-7015
- Source identifiers:
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963671
Item Description
- Language:
- English
- Pubs id:
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pubs:963671
- UUID:
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uuid:c9b82ccd-ad2d-49dd-a67c-1c6bb306ff9a
- Local pid:
- pubs:963671
- Deposit date:
- 2019-01-18
Terms of use
- Copyright holder:
- Ashley et al
- Copyright date:
- 2019
- Notes:
- © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
- Licence:
- CC Attribution (CC BY)
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