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Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.

Abstract:

The spectrum of the anti-human immunodeficiency virus (HIV) neutralizing immune response has been analyzed by the production and characterization of monoclonal antibodies (mAbs) to the viral envelope glycoproteins, gp41 and gp120. Little is known, however, about the neutralization mechanism of these antibodies. Here we show that the binding of a group of neutralizing mAbs that react with regions of the gp120 molecule associated with and including the V2 and V3 loops, the C4 domain and support...

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Publication status:
Published

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Publisher copy:
10.1084/jem.183.2.473

Authors


Poignard, P More by this author
Naniche, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, Jenner Institute
Journal:
The Journal of experimental medicine
Volume:
183
Issue:
2
Pages:
473-484
Publication date:
1996-02-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:c98f2b0c-8d18-4666-afbc-d08631267950
Source identifiers:
16058
Local pid:
pubs:16058

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