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VEGF‐A inhibits agonist‐mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells

Abstract:

Vascular endothelial growth factor A (VEGF‐A) is a potent permeability and angiogenic factor that is also associated with the remodelling of the microvasculature. Elevated VEGF‐A levels are linked to a significant increase in the risk of cardiovascular dysfunction, although it is unclear how VEGF‐A has a detrimental, disease‐related effect. Small resistance arteries are central determinants of peripheral resistance and endothelium‐dependent hyperpolarization (EDH) is the predominant mechanism...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1113/JP275793

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Beckett, T More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Oxford college:
Magdalen College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Grant:
PG/14/58/30998; FS/13/16/30199
Publisher:
Wiley Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
596
Issue:
16
Pages:
3553-3566
Publication date:
2018-06-03
Acceptance date:
2018-05-15
DOI:
ISSN:
0022-3751
Pubs id:
pubs:891041
URN:
uri:c97dbb18-9ab0-4df6-ae19-e705e3da92ae
UUID:
uuid:c97dbb18-9ab0-4df6-ae19-e705e3da92ae
Local pid:
pubs:891041

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