Journal article
The role of the salience network in adolescent impulsivity using memory tasks and neuroimaging
- Abstract:
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Background
This study investigated potential behavioral and neural biomarkers of adolescent impulsivity by analyzing adolescent responses in a memory test and examining task-independent brain connectivity.
MethodsThis research utilized immediate and delayed memory tasks, together with a similar distractor memory task (SMT), to examine adolescent impulsivity and its correlation with neural cognitive control strategies. Ninety-five healthy, right-handed teenagers (27 females, average age 14.9 years) participated in the functional magnetic resonance imaging (fMRI) sessions.
ResultsElevated impulsivity correlates with an increased number of errors during target trials and a higher incidence of false alarms during catch trials. Neural activity and connectivity involving the insula and dorsal anterior cingulate cortex (dACC) are significantly associated with behavioral responses and individual impulsivity. Notably, both task-modulated and resting-state (intrinsic) coupling between the insula and locus coeruleus (LC), as well as between the dACC and LC, demonstrate significant positive correlation with impulsivity. These findings indicate that insula-LC and dACC-LC connectivity strength serve as reliable indicators of impulsivity.
ConclusionsThe results indicate that the connection between the salience network and the noradrenergic locus coeruleus may function as a consistent neural indicator of impulsivity. Our findings indicate that this method can discern reliable brain biomarkers for impulsivity and can guide interventions aimed at enhancing self-control during adolescence.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s43856-025-01212-y
Authors
- Funder identifier:
- https://ror.org/03cpyc314
- Grant:
- RS-2023-00223559
- Publisher:
- Springer Nature
- Journal:
- Communications Medicine More from this journal
- Volume:
- 5
- Issue:
- 1
- Article number:
- 500
- Publication date:
- 2025-11-27
- Acceptance date:
- 2025-10-21
- DOI:
- EISSN:
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2730-664X
- Pmid:
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41310178
- Language:
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English
- Pubs id:
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2352218
- UUID:
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uuid_c95e0a8f-e1a1-4199-aebf-843136bfd55d
- Local pid:
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pubs:2352218
- Source identifiers:
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W4416758228
- Deposit date:
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2025-12-19
- ARK identifier:
Terms of use
- Copyright holder:
- Kim et al.
- Copyright date:
- 2025
- Rights statement:
- © The Author(s) 2025. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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