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B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area.

Abstract:

To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigen-specific memory B cells from donors in an area where malaria is endemic. We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens: the C-terminal portion of merozoite surface protein 1 (MSP1(19)), apical membrane antigen 1 (AMA1), and the cysteine-rich interdomain region 1 alpha (CIDR1 alpha ) of a protein from t...

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Publication status:
Published

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Publisher copy:
10.1086/429671

Authors


Dorfman, JR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Ndungu, FM More by this author
Langhorne, J More by this author
Kortok, MM More by this author
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Journal:
The Journal of infectious diseases
Volume:
191
Issue:
10
Pages:
1623-1630
Publication date:
2005-05-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:c95a95bb-4300-4861-9f26-b1835afc502a
Source identifiers:
39439
Local pid:
pubs:39439

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