Cdc2 activation is not required for thymocyte apoptosis.

Journal article

Apoptosis is a mode of cell death characterized by chromatin condensation and disassembly of the nuclear lamina, processes that are also characteristic of mitosis. The apparent similarity between the two events, together with observations that apoptosis can occur following G2 arrest, has led to the suggestion that apoptosis could be a defective form of mitosis. Further support for this idea comes from the recent description of activation of the p34cdc2 protein kinase (Cdc2), the universal M-p...

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Authors: Norbury, C; MacFarlane, M; Fearnhead, H; Cohen, G

• Publication status: Published
• Journal: Biochemical and biophysical research communications
• Volume: 202
• Issue: 3
• Pages: 1400-1406
• Publication date: 1994-08-01
• DOI: 10.1006/bbrc.1994.2086
• EISSN: 1090-2104
• ISSN: 0006-291X
• Language: English
• Keywords: Apoptosis; Lymphocytes; Cells, Cultured; Thymus Gland; Male; Rats; G0 Phase; Etoposide; Dexamethasone; Animals; Rats, Inbred F344; Tosyllysine Chloromethyl Ketone; CDC2 Protein Kinase; Enzyme Activation