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Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.

Abstract:

Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1; chromosome 5) play a significant role in the parasite's resistance to a variety of antimalarials and also modulate CQR. To compare patterns of genetic variation at Pfcrt and Pfmdr1 loci, we investigated 460 blood samples from P. falciparum-infected patients from four Asian, three African, and three South...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00089-08

Authors


Mehlotra, RK More by this author
Mattera, G More by this author
Bockarie, MJ More by this author
Maguire, JD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Antimicrobial agents and chemotherapy
Volume:
52
Issue:
6
Pages:
2212-2222
Publication date:
2008-06-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:c94c1017-fb9c-46c9-9d02-319a1066e379
Source identifiers:
81637
Local pid:
pubs:81637

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