- Abstract:
-
Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1; chromosome 5) play a significant role in the parasite's resistance to a variety of antimalarials and also modulate CQR. To compare patterns of genetic variation at Pfcrt and Pfmdr1 loci, we investigated 460 blood samples from P. falciparum-infected patients from four Asian, three African, and three South...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/aac.00089-08
-
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- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 52
- Issue:
- 6
- Pages:
- 2212-2222
- Publication date:
- 2008-06-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:c94c1017-fb9c-46c9-9d02-319a1066e379
- Source identifiers:
-
81637
- Local pid:
- pubs:81637
- Copyright date:
- 2008
Journal article
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum.
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