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Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

Abstract:

Background Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner membrane and converts that energy into heat. It is unclear whether cancer cells can exhibit autonomous thermogenesis. Previously, we found that the knockdown of hypoxia-inducible fatty acid binding protein 7 (FABP7) increased reactive oxygen species (ROS) in brea...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s40170-020-00219-4

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Role:
Author
ORCID:
0000-0002-4738-8351
Publisher:
BioMed Central
Journal:
Cancer and Metabolism More from this journal
Volume:
8
Issue:
1
Article number:
13
Publication date:
2020-07-06
Acceptance date:
2020-05-18
DOI:
EISSN:
2049-3002
ISSN:
2049-3002
Pmid:
32647572
Language:
English
Keywords:
Pubs id:
1119662
Local pid:
pubs:1119662
Deposit date:
2020-08-20

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