Matrix metalloproteinases in cancer.

Journal article

Abstract:: The extracellular matrix (ECM) holds cells together and maintains the three-dimensional structure of the body. It also plays critical roles in cell growth, differentiation, survival and motility. For a tumour cell to metastasize from the primary tumour to other organs, it must locally degrade ECM components that are the physical barriers for cell migration. The key enzymes responsible for ECM breakdown are matrix metalloproteinases (MMPs). To date, 23 MMP genes have been identified in humans ...
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Institution:

University of Oxford

Division:

MSD

Department:

NDORMS

Role:

Author

Institution:

University of Oxford

Division:

MSD

Department:

NDORMS

Role:

Author

Language:: English
Keywords:: Matrix Metalloproteinases

Humans

Neoplasms

Neoplasm Metastasis

Models, Biological

Neoplasm Invasiveness

Models, Molecular

Animals
Pubs id:: pubs:224008
UUID:: uuid:c91bd0f3-8655-4f18-8db3-80cbd7d02ce1
Local pid:: pubs:224008
Source identifiers:: 224008
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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