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Penicillin allergy assessment pathway versus usual clinical care for primary care patients with a penicillin allergy record in the UK (ALABAMA): an open-label, multicentre, randomised controlled trial

Abstract:
Background
Penicillin allergy labels in medical records are common, often incorrect, and associated with increased antibiotic use and worse health outcomes. We aimed to establish whether a penicillin allergy assessment pathway initiated in primary care could safely improve use of penicillins.

Methods
ALABAMA was a multicentre, open-label, randomised pragmatic trial with embedded process and cost-effectiveness evaluations. Participants came from 5... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.lanprc.2025.100006

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0001-5438-5290

Contributors



Publisher:
Elsevier
Journal:
Lancet Primary Care More from this journal
Volume:
1
Issue:
1
Article number:
100006
Publication date:
2025-07-14
Acceptance date:
2025-05-06
DOI:
EISSN:
3050-5143


Language:
English
Pubs id:
2242313
Local pid:
pubs:2242313
Deposit date:
2025-07-11
ARK identifier:

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