Thesis
Impact of host restriction factors and capsid evolution on HIV disease progression
- Abstract:
-
HIV-1 is responsible for the global HIV pandemic whereas HIV-2 has mostly been limited to West Africa. The key to their successful spread is their unparalleled ability to adapt to the host immune system. The contemporary HIV pandemics are the latest iteration in a millennia-long evolutionary arms race between retroviruses and their hosts. Two host restriction factors which have been important actors in this arms race are TRIM5α and its paralogue TRIM22. TRIM5α targets the retroviral capsid...
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Authors
Contributors
+ Rowland-Jones, S
Department:
Oxford University
Role:
Supervisor
+ Esbjornsson, J
Department:
Lund University
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:c8fb6800-bf10-42a1-a072-dd810e8f9462
- Deposit date:
- 2019-12-03
Terms of use
- Copyright holder:
- Boswell, M
- Copyright date:
- 2019
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