- Abstract:
-
BACKGROUND: RDP58 is a novel anti-inflammatory d-amino acid decapeptide that inhibits synthesis of proinflammatory cytokines by disrupting cell signaling at the pre-MAPK MyD88-IRAK-TRAF6 protein complex. We therefore evaluated its efficacy and safety in parallel multicenter, double-blind, randomized concept studies in ulcerative colitis (UC). METHODS: In the first trial, 34 patients with mild to moderate active UC were randomized (1:2) to placebo (n = 13) or RDP58 100 mg (n = 21). In the sec...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/01.mib.0000172807.26748.16
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- Journal:
- Inflammatory bowel diseases
- Volume:
- 11
- Issue:
- 8
- Pages:
- 713-719
- Publication date:
- 2005-08-05
- DOI:
- EISSN:
-
1536-4844
- ISSN:
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1078-0998
- URN:
-
uuid:c8eaca4b-0bd3-498c-85bb-dcd26ce215a7
- Source identifiers:
-
111485
- Local pid:
- pubs:111485
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.
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