Journal article icon

Journal article

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.

Abstract:

Mutations in the PPP6C catalytic subunit of protein phosphatase 6 (PP6) are drivers for the development of melanoma. Here, we analyse a panel of melanoma-associated mutations in PPP6C and find that these generally compromise assembly of the PP6 holoenzyme and catalytic activity towards a model substrate. Detailed analysis of one mutant, PPP6C-H114Y, in both primary melanoma and engineered cell lines reveals it is destabilized and undergoes increased proteasome-mediated turnover. Global analys...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1242/jcs.128397

Authors


Journal:
Journal of cell science More from this journal
Volume:
126
Issue:
Pt 15
Pages:
3429-3440
Publication date:
2013-08-01
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Language:
English
Keywords:
Pubs id:
pubs:401146
UUID:
uuid:c8e12f75-5b4c-40b2-b16f-0d9268f0ec83
Local pid:
pubs:401146
Source identifiers:
401146
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP