Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.

Journal article

Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,...

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Authors: Pillas, D; Hoggart, C; Evans, D; O'Reilly, P; Sipilä, K

• Publication status: Published
• Journal: PLoS genetics
• Volume: 6
• Issue: 2
• Pages: e1000856
• Publication date: 2010-02-01
• DOI: 10.1371/journal.pgen.1000856
• EISSN: 1553-7404
• ISSN: 1553-7390
• Language: English
• Keywords: Longitudinal Studies; Meta-Analysis as Topic; Genetic Loci; Tooth, Deciduous; Tooth Eruption; Parturition; Genome-Wide Association Study; Female; Male; Polymorphism, Single Nucleotide; Infant; Linkage Disequilibrium; England; Finland; Humans; Alleles; Genotype