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Effects of endotoxin exposure on cationic amino acid transporter function in ovine peripheral blood mononuclear cells.

Abstract:

Rodent models of sepsis differ from clinical human disease in that humans make substantially less whole-body nitric oxide and have different cellular responses to endotoxin. Sheep, when exposed to endotoxin, behave in a manner more similar to humans. Many studies of rodent peripheral blood mononuclear cells (PBMCs) exposed to endotoxin demonstrate increased cationic amino acid transporter function (particularly through the y+ transporter) to supply arginine substrate to upregulated nitric oxi...

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Publication status:
Published

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Publisher copy:
10.1113/eph8802474

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Experimental physiology
Volume:
88
Issue:
2
Pages:
201-208
Publication date:
2003-03-05
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
URN:
uuid:c8dbf9a8-205f-44af-b8a0-3fb1892d1a29
Source identifiers:
113318
Local pid:
pubs:113318

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