- Abstract:
-
Rodent models of sepsis differ from clinical human disease in that humans make substantially less whole-body nitric oxide and have different cellular responses to endotoxin. Sheep, when exposed to endotoxin, behave in a manner more similar to humans. Many studies of rodent peripheral blood mononuclear cells (PBMCs) exposed to endotoxin demonstrate increased cationic amino acid transporter function (particularly through the y+ transporter) to supply arginine substrate to upregulated nitric oxi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1113/eph8802474
-
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- Journal:
- Experimental physiology
- Volume:
- 88
- Issue:
- 2
- Pages:
- 201-208
- Publication date:
- 2003-03-05
- DOI:
- EISSN:
-
1469-445X
- ISSN:
-
0958-0670
- URN:
-
uuid:c8dbf9a8-205f-44af-b8a0-3fb1892d1a29
- Source identifiers:
-
113318
- Local pid:
- pubs:113318
- Copyright date:
- 2003
Journal article
Effects of endotoxin exposure on cationic amino acid transporter function in ovine peripheral blood mononuclear cells.
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