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Journal article

PRMT5 is a critical regulator of breast cancer stem cell function via histone methylation and FOXP1 expression..

Abstract:

Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs). Identification of factors critical for BCSC function is therefore vital for the development of therapies. Here, we identify the arginine methyltransferase PRMT5 as a key in vitro and in vivo regulator of BCSC proliferation and self-renewal and establish FOXP1, a winged helix/forkhead transcription factor, as a critical effector of PRMT...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.11.096

Authors


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University of Birmingham More from this funder
Breast Cancer Now More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
21
Issue:
12
Pages:
3498-3513
Publication date:
2017-12-05
Acceptance date:
2017-11-28
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:813048
URN:
uri:c8dac21c-ded6-4d62-9b35-2dc22ab73d57
UUID:
uuid:c8dac21c-ded6-4d62-9b35-2dc22ab73d57
Local pid:
pubs:813048

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