PRMT5 is a critical regulator of breast cancer stem cell function via histone methylation and FOXP1 expression..
Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs). Identification of factors critical for BCSC function is therefore vital for the development of therapies. Here, we identify the arginine methyltransferase PRMT5 as a key in vitro and in vivo regulator of BCSC proliferation and self-renewal and establish FOXP1, a winged helix/forkhead transcription factor, as a critical effector of PRMT...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 5.0MB)
- Publisher copy:
- Copyright holder:
- Farnie et al
- Copyright date:
- © 2017 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- CC Attribution (CC BY)