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Journal article

Germline DNA repair gene mutations in young-onset prostate cancer cases in the UK: evidence for a more extensive genetic panel

Abstract:

BACKGROUND: Rare germline mutations in DNA repair genes are associated with prostate cancer (PCa) predisposition and prognosis.

OBJECTIVE: To quantify the frequency of germline DNA repair gene mutations in UK PCa cases and controls, in order to more comprehensively evaluate the contribution of individual genes to overall PCa risk and likelihood of aggressive disease.

DESIGN, SETTING, AND PARTICIPANTS: We sequenced 167 DNA rep...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Name:
Department of Health
Grant:
NF-SI-0513-10121
More from this funder
Name:
National Institute for Health Research
Grant:
NF-SI-0513-10121
Publisher:
Elsevier
Journal:
European Urology More from this journal
Volume:
76
Issue:
3
Pages:
329-337
Publication date:
2019-02-15
Acceptance date:
2019-01-31
DOI:
EISSN:
1873-7560
ISSN:
0302-2838
Pmid:
30777372
Language:
English
Keywords:
Pubs id:
pubs:975961
UUID:
uuid:c8c9b7fb-cc1a-4e54-bc95-6c011130bade
Local pid:
pubs:975961
Source identifiers:
975961
Deposit date:
2019-06-19

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