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The association between vaccine coverage and herd protection: exploratory analyses of a cluster-randomised trial of Vi conjugate vaccine

Abstract:
Background
Indirect protection from the typhoid conjugate vaccine (TCV) has been negligible, possibly due to vaccination being restricted to children, which may have limited the overall vaccine coverage needed to sufficiently interrupt transmission dynamics across endemic populations. In this study herd protection was evaluated in households and schools with different TCV coverages by conducting secondary analyses of a double-blind cluster-randomised trial on TCV in Bangla... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.eclinm.2026.103863

Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-6628-5147
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-2342-8531


More from this funder
Funder identifier:
https://ror.org/0456r8d26
Grant:
OPP1151153
More from this funder
Funder identifier:
https://ror.org/03sbpja79


Publisher:
Elsevier
Journal:
EClinicalMedicine More from this journal
Volume:
94
Article number:
103863
Publication date:
2026-04-15
Acceptance date:
2026-03-19
DOI:
EISSN:
2589-5370
ISSN:
2589-5370


Language:
English
Keywords:
Pubs id:
2407195
Local pid:
pubs:2407195
Source identifiers:
W7154454863
Deposit date:
2026-04-27
ARK identifier:

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