Journal article
The evolving epidemic of breast cancer in sub-Saharan Africa. Results from the African Cancer Registry Network
- Abstract:
- Breast cancer (BC) is the leading cause of cancer in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported in Uganda and Zimbabwe. However, the magnitude of these rising trends in pre- and post-menopausal women is unknown in most African countries. We used data from the African Cancer Registry Network on incident breast cancers in women from 11 population-based cancer registries in 10 countries representing each of the four SSA regions. We explored incidence changes among women before and after age 50 by calendar period and, where possible, generational effects in this unique sub-Saharan African cohort. Temporal trends revealed increasing incidence rates in all registries during the study period, except in Nairobi where rates stabilized during 2010-2014 after rapidly increasing from 2003-2010 (APC = 8.5 95%, CI:3.0-14.2). The cumulative risk varied between and within regions, with the highest risks observed in Nairobi-Kenya, Mauritius and the Seychelles. There were similar or more rapidly increasing incidence rates in women aged 50+ compared to women <50 years in all registries except The Gambia. Birth cohort analyses revealed increases in the incidence rates in successive generations of women aged 45 and over in Harare-Zimbabwe and Kampala-Uganda. In conclusion, the incidence of BC is increasing rapidly in many parts of Africa; however, the magnitude of these changes differs. These results highlight the need for urgent actions across the cancer continuum from in-depth risk factor studies to provision of adequate therapy as well as the necessity of supporting the maintenance of good quality population-based cancer registration in Africa.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1002/ijc.33014
Authors
- Publisher:
- Wiley
- Journal:
- International Journal of Cancer More from this journal
- Volume:
- 147
- Issue:
- 8
- Pages:
- 2131-2141
- Publication date:
- 2020-04-19
- Acceptance date:
- 2020-04-01
- DOI:
- EISSN:
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1097-0215
- ISSN:
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0020-7136
- Pmid:
-
32306390
- Language:
-
English
- Keywords:
- Pubs id:
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1101295
- Local pid:
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pubs:1101295
- Deposit date:
-
2020-04-27
- ARK identifier:
Terms of use
- Copyright holder:
- Joko-Fru et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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