Journal article icon

Journal article

Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations.

Abstract:

To induce a deployable level of efficacy, a successful malaria vaccine would likely benefit from both potent cellular and humoral immunity. These requirements are met by a heterologous prime-boost immunization strategy employing a chimpanzee adenovirus vector followed by modified vaccinia Ankara (MVA), both encoding the pre-erythrocytic malaria antigen ME-thrombospondin-related adhesive protein (TRAP), with high immunogenicity and significant efficacy in UK adults. We undertook two phase 1b o...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/mt.2014.109

Authors


Expand authors...
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
22
Issue:
11
Pages:
1992-2003
Publication date:
2014-11-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:c8c31450-cc87-4be2-978a-cfae569b2e25
Source identifiers:
470561
Local pid:
pubs:470561
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP