Journal article
Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations.
- Abstract:
-
To induce a deployable level of efficacy, a successful malaria vaccine would likely benefit from both potent cellular and humoral immunity. These requirements are met by a heterologous prime-boost immunization strategy employing a chimpanzee adenovirus vector followed by modified vaccinia Ankara (MVA), both encoding the pre-erythrocytic malaria antigen ME-thrombospondin-related adhesive protein (TRAP), with high immunogenicity and significant efficacy in UK adults. We undertook two phase 1b o...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/mt.2014.109
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Authors
Bibliographic Details
- Journal:
- Molecular therapy : the journal of the American Society of Gene Therapy
- Volume:
- 22
- Issue:
- 11
- Pages:
- 1992-2003
- Publication date:
- 2014-11-05
- DOI:
- EISSN:
-
1525-0024
- ISSN:
-
1525-0016
- URN:
-
uuid:c8c31450-cc87-4be2-978a-cfae569b2e25
- Source identifiers:
-
470561
- Local pid:
- pubs:470561
Item Description
- Language:
- English
Terms of use
- Copyright date:
- 2014
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