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Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development.

Abstract:

The midgut environment of anopheline mosquitoes plays an important role in the development of the malaria parasite. Using genetic manipulation of anopheline mosquitoes to change the environment in the mosquito midgut may inhibit development of the malaria parasite, thus blocking malaria transmission. Here we generate transgenic Anopheles stephensi mosquitoes that express the C-type lectin CEL-III from the sea cucumber, Cucumaria echinata, in a midgut-specific manner. CEL-III has strong and ra...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.0030192

Authors


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Ministry of Education of Japan More from this funder
Ministry of Culture of Japan More from this funder
Ministry of Sports of Japan More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
3
Issue:
12
Pages:
e192
Publication date:
2007-12-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:c8c23089-6bfb-4015-816c-b0066eedb745
Source identifiers:
257938
Local pid:
pubs:257938

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