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Olefin cross-metathesis-based approaches to furans: procedures for the preparation of di- and trisubstituted variants.

Abstract:

Olefin cross-metathesis (CM)-based protocols enable short, flexible and regiocontrolled access to substituted furan derivatives. Specifically, CM of allylic alcohol and enone components provides γ-hydroxyenone intermediates that are cycloaromatized to the final furan derivatives on exposure to either acid or a discrete Heck arylation step. This latter process concomitantly introduces an extra substituent onto the furan target with complete control of regiochemistry. The methodology described ...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2010.147

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Nature protocols More from this journal
Volume:
5
Issue:
12
Pages:
2005-2010
Publication date:
2010-12-01
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Language:
English
Keywords:
Pubs id:
pubs:103637
UUID:
uuid:c8acb363-ba76-4917-bf70-cf4727441816
Local pid:
pubs:103637
Source identifiers:
103637
Deposit date:
2012-12-19

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