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CD45 in memory and disease.

Abstract:

CD45 (the leukocyte common antigen) is known to function as a tyrosine phosphatase in leukocyte signaling. Biochemical studies indicate that CD45 is involved in the regulation both of T cell receptor-associated kinases and Janus kinases that transmit signals from cytokine receptors. However, the function of the different isoforms of CD45 generated by complex alternative splicing, and indeed the role of the whole extracellular domain of the molecule, remain mysterious. Analysis of CD45 knock-o...

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Authors


Tchilian, EZ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Archivum immunologiae et therapiae experimentalis
Volume:
50
Issue:
2
Pages:
85-93
Publication date:
2002
EISSN:
1661-4917
ISSN:
0004-069X
URN:
uuid:c89d7632-7085-47ea-bef2-d365cc6e4407
Source identifiers:
32112
Local pid:
pubs:32112

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