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Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus

Abstract:

Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and is widely accepted as playing a crucial role in disease pathology. To understand the relationship between toxicity and bacterial virulence in greater depth, we studied two sequenced collections of the major human pathogen Staphylococcus aureus and found an unexpected inve...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pbio.1002229

Authors


Uhlemann, AC More by this author
Austin, ED More by this author
Yokoyama, M More by this author
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Funding agency for:
Young, BC
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Funding agency for:
Wilson, DJ
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Funding agency for:
Wilson, DJ
National Institute for Health Research More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS biology Journal website
Volume:
13
Issue:
9
Pages:
e1002229
Publication date:
2015-09-05
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:c89119e0-6d97-4908-90b6-93b5b88ad29c
Source identifiers:
543231
Local pid:
pubs:543231
Language:
English

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