Journal article
Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties
- Abstract:
- The cortex of the femoral neck is a key structural element of the human body, yet there is not a reliable metric for predicting the mechanical properties of the bone in this critical region. This study explored the use of a range of non-destructive metrics to measure femoral neck cortical bone stiffness at the millimetre length scale. A range of testing methods and imaging techniques were assessed for their ability to measure or predict the mechanical properties of cortical bone samples obtained from the femoral neck of hip replacement patients. Techniques that can potentially be applied in vivo to measure bone stiffness, including computed tomography (CT), bulk wave ultrasound (BWUS) and indentation, were compared against in vitro techniques, including compression testing, density measurements and resonant ultrasound spectroscopy. Porosity, as measured by micro-CT, correlated with femoral neck cortical bone’s elastic modulus and ultimate compressive strength at the millimetre length scale. Large-tip spherical indentation also correlated with bone mechanical properties at this length scale but to a lesser extent. As the elastic mechanical properties of cortical bone correlated with porosity, we would recommend further development of technologies that can safely measure cortical porosity in vivo.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1038/s41598-019-43686-6
Authors
+ National Institute for Health Research
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- Grant:
- Imperial Biomedical Research Centr
+ The Royal College of Surgeons of England
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- Grant:
- Dunhill Medical Trust Clinical Research Fellowship
- Publisher:
- Springer Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 9
- Issue:
- 1
- Publication date:
- 2019-05-15
- Acceptance date:
- 2019-04-23
- DOI:
- ISSN:
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2045-2322
- Language:
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English
- Pubs id:
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pubs:1000001
- UUID:
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uuid:c87f7d77-2247-46f4-8299-5b6c4aa3c099
- Local pid:
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pubs:1000001
- Source identifiers:
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1000001
- Deposit date:
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2019-05-21
Terms of use
- Copyright holder:
- Boughton et al
- Copyright date:
- 2019
- Notes:
-
© The Author(s) 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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