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Clearance of asymptomatic P. falciparum Infections Interacts with the number of clones to predict the risk of subsequent malaria in Kenyan children.

Abstract:

BACKGROUND: Protective immunity to malaria is acquired after repeated infections in endemic areas. Asymptomatic multiclonal P. falciparum infections are common and may predict host protection. Here, we have investigated the effect of clearing asymptomatic infections on the risk of clinical malaria. METHODS: Malaria episodes were continuously monitored in 405 children (1-6 years) in an area of moderate transmission, coastal Kenya. Blood samples collected on four occasions were assessed by gen...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0016940

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More from this funder
Name:
Biomedical Research Centre in Oxford
Funding agency for:
Bejon, P
More from this funder
Name:
NIHR Biomedical Research Centre Oxford
More from this funder
Name:
Swedish Society for Tropical Medicine and International Health
More from this funder
Name:
Sigurd and Elsa Goljes Foundation
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
6
Issue:
2
Article number:
e16940
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:c87573ed-aea6-4833-b797-ab34f1ed4730
Local pid:
pubs:124552
Source identifiers:
124552
Deposit date:
2012-12-19

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