Journal article
Identification and optimization of 4-anilinoquinolines as inhibitors of cyclin G associated kinase
- Abstract:
-
4-Anilinoquinolines were identified as potent and narrow-spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4-anilino group and the 6,7-quinoline substituents produced GAK inhibitors with nanomolar activity, over 50 000-fold selectivity relative to other members of the numb-associated kinase (NAK) subfamily, and a compound (6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine; 49) with a nar...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 879.4KB)
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- Publisher copy:
- 10.1002/cmdc.201700663
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Authors
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- ChemMedChem Journal website
- Volume:
- 13
- Issue:
- 1
- Pages:
- 48–66
- Publication date:
- 2017-11-27
- Acceptance date:
- 2017-10-26
- DOI:
- EISSN:
-
1860-7187
- ISSN:
-
1860-7179
- Pmid:
-
29072804
- Source identifiers:
-
803558
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:803558
- UUID:
-
uuid:c872af63-724b-4860-aad8-f0f8cd9760bb
- Local pid:
- pubs:803558
- Deposit date:
- 2017-12-20
Terms of use
- Copyright holder:
- Wiley-VCH Verlag GmbH & Co KGaA, Weinheim
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/cmdc.201700663
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