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Journal article

HLA class I typing by PCR: HLA-B27 and an African B27 subtype.

Abstract:

We describe a rapid method of HLA class I typing using the polymerase chain reaction and oligonucleotide hybridisation that eliminates the requirements for viable lymphocytes and allows subtypes to be defined. We have used this to demonstrate that the predominant subtype of HLA-B27 in the Gambia, West Africa, is HLA-B*2703, which is very rare or absent in other racial groups. This subtype differs from the common Caucasian HLA-B27 subtypes in its recognition by cytotoxic T cells. We propose th...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Lancet (London, England)
Volume:
337
Issue:
8742
Pages:
640-642
Publication date:
1991-03-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
33483
Language:
English
Keywords:
Pubs id:
pubs:33483
UUID:
uuid:c867ec33-6c71-4b97-8043-268bb51f8f17
Local pid:
pubs:33483
Deposit date:
2012-12-19

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