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HLA class I typing by PCR: HLA-B27 and an African B27 subtype.

Abstract:

We describe a rapid method of HLA class I typing using the polymerase chain reaction and oligonucleotide hybridisation that eliminates the requirements for viable lymphocytes and allows subtypes to be defined. We have used this to demonstrate that the predominant subtype of HLA-B27 in the Gambia, West Africa, is HLA-B*2703, which is very rare or absent in other racial groups. This subtype differs from the common Caucasian HLA-B27 subtypes in its recognition by cytotoxic T cells. We propose th...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Allsopp, CE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Anstey, NM More by this author
Greenwood, BM More by this author
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Journal:
Lancet (London, England)
Volume:
337
Issue:
8742
Pages:
640-642
Publication date:
1991-03-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:c867ec33-6c71-4b97-8043-268bb51f8f17
Source identifiers:
33483
Local pid:
pubs:33483

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