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Data quality control in genetic case-control association studies.

Abstract:

This protocol details the steps for data quality assessment and control that are typically carried out during case-control association studies. The steps described involve the identification and removal of DNA samples and markers that introduce bias. These critical steps are paramount to the success of a case-control study and are necessary before statistically testing for association. We describe how to use PLINK, a tool for handling SNP data, to perform assessments of failure rate per indiv...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2010.116

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Nature protocols
Volume:
5
Issue:
9
Pages:
1564-1573
Publication date:
2010-09-01
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
Source identifiers:
73355
Language:
English
Keywords:
Pubs id:
pubs:73355
UUID:
uuid:c859f0b5-db1a-4a30-a9e9-be236f356848
Local pid:
pubs:73355
Deposit date:
2012-12-19

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