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Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

Abstract:

Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein (HDL) and has well documented anti-inflammatory properties. To better understand the cellular and molecular basis of the anti-inflammatory actions of apoA1, we explored the effect of acute human apoA1 exposure on the migratory capacity of monocyte-derived cells in vitro and in vivo. Acute (20–60 min) apoA1 treatment induced a substantial (50–90%) reduction in macrophage chemotaxis to a range of chemoattractan...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.15190

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Funding agency for:
Iqbal, A
Grant:
RG/15/10/31485
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Funding agency for:
McNeill, E
Grant:
RG/15/10/31485
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Funding agency for:
Channon, K
Grant:
RG/15/10/31485
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Funding agency for:
Greaves, D
Grant:
IE120747
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Funding agency for:
Greaves, D
Grant:
IE120747
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
5
Pages:
E15190
Publication date:
2016-08-30
Acceptance date:
2016-08-29
DOI:
EISSN:
2050-084X
ISSN:
0021-9150
Pmid:
27572261
Source identifiers:
593527
Language:
English
Keywords:
Pubs id:
pubs:593527
UUID:
uuid:c83dc24c-4a51-4484-b3f1-1e7681c894db
Local pid:
pubs:593527
Deposit date:
2016-09-20

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