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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Abstract:

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21....

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Publisher copy:
10.1038/ng.922

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Journal:
Nat Genet
Volume:
43
Issue:
10
Pages:
1005-1011
Publication date:
2011-10-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:c83b1981-7349-4fc8-b955-c8d960092eb6
Source identifiers:
175209
Local pid:
pubs:175209

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