- Abstract:
-
An enhancer region in the type I collagen alpha 2 chain (pro-Col1a2) promoter has been previously identified approximately -17 kb away from the transcription start site. This upstream region termed the far-upstream-enhancer contains three DNAse I hypersensitive sites and has been shown to be conserved between mouse and human genes. In this study, we used transgenic mice harbouring the complete promotor sequence of the pro-Col1a2 gene up to -17 kb to examine the role of this enhancer in the ex...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.matbio.2003.12.002
-
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- Journal:
- Matrix biology : journal of the International Society for Matrix Biology
- Volume:
- 22
- Issue:
- 8
- Pages:
- 619-628
- Publication date:
- 2004-02-05
- DOI:
- EISSN:
-
1569-1802
- ISSN:
-
0945-053X
- URN:
-
uuid:c8256073-b15d-4bc9-aa9e-29ff355a773e
- Source identifiers:
-
223492
- Local pid:
- pubs:223492
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.
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