Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies

Journal article

Aphids are small insects that have developed specialized mouthparts and effector proteins to establish long-term relationships with plants. The peach-potato aphid Myzus persicae is a generalist, feeding on many plant species and capable of transmitting numerous pathogens. This study reveals how host-responsive cathepsin B (CathB) proteins in the oral secretions of M. persicae facilitate aphid survival by modulating plant immune responses. Host-responsive CathB proteins localize to plant processing bodies (p-bodies), cytoplasmic ribonucleoprotein granules involved in messenger RNA storage or decay. Upon localization, these CathB proteins recruit key immune regulators EDS1, PAD4, and ADR1 to these bodies, suppressing plant defenses. A plant protein, Acd28.9 (Hsp20 family), counteracts this CathB activity and contributes to plant resistance to aphids. These findings highlight an unexpected role for p-bodies in plant immunity and uncover a plant resistance mechanism to aphid infestation.

Authors: Liu, Q; Neefjes, ACM; Singh, A; Kobylinska, R; Mugford, ST

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Association for the Advancement of Science
• Journal: Science Advances
• Volume: 11
• Issue: 29
• Pages: eadv1447
• Publication date: 2025-07-16
• Acceptance date: 2025-06-06
• DOI: 10.1126/sciadv.adv1447
• EISSN: 2375-2548
• ISSN: 2375-2548
• Pmid: 40668932
• Language: English
• Keywords: Plant Proteins; Insect Proteins; Plant Diseases; Animals; Plant Immunity; Gene Expression Regulation, Plant; Cathepsin B; Aphids