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Insights into mucosal-associated invariant T cell biology from studies of invariant natural killer T cells

Abstract:

Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity. They express semi-invariant T cell receptors (TCRs) and recognize unconventional non-peptide ligands bound to the MHC Class I-like molecules MR1 and CD1d, respectively. MAIT cells and iNKT cells exhibit an effector-memory phenotype and are enriched within the liver and at mucosal sites. In humans, MAIT cell frequen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3389/fimmu.2018.01478

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Oxford college:
Merton College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Garner, LC
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Funding agency for:
Klenerman, P
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Funding agency for:
Klenerman, P
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Funding agency for:
Klenerman, P
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Issue:
2018
Pages:
1478
Publication date:
2018-06-28
Acceptance date:
2018-06-14
DOI:
ISSN:
1664-3224
Pubs id:
pubs:870155
URN:
uri:c7f7e862-e9ab-478c-8fc3-55feaaa69a1f
UUID:
uuid:c7f7e862-e9ab-478c-8fc3-55feaaa69a1f
Local pid:
pubs:870155

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