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Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.

Abstract:

The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact mouse pancreatic islets. Three types of electrical activity were observed corresponding to alpha-, beta- and delta-cells. The delta-cells were electrically active in the presence of glucose but lacked the oscillatory pattern seen in the beta-cells. By contrast, the alpha-cells were electrically silent at high glucose concentrations but action potentials could be elicited by re...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Journal of physiology More from this journal
Volume:
528
Issue:
Pt 3
Pages:
497-507
Publication date:
2000-11-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751

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