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SF3B1 mutant myelodysplastic syndrome: Recent advances

Abstract:

The myelodysplastic syndromes (MDS) are common myeloid malignancies. Mutations in genes encoding different components of the spliceosome occur in more than half of all MDS patients. SF3B1 is the most frequently mutated splicing factor gene in MDS, and there is a strong association between SF3B1 mutations and the presence of ring sideroblasts in the bone marrow of MDS patients. It has been recently proposed that SF3B1 mutant MDS should be recognized as a distinct nosologic entity. Splicing fac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jbior.2020.100776

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-6122-0221
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-4330-2928
Publisher:
Elsevier Publisher's website
Journal:
Advances in Biological Regulation Journal website
Volume:
79
Article number:
100776
Publication date:
2020-12-25
Acceptance date:
2020-12-14
DOI:
EISSN:
2212-4926
Pmid:
33358369
Language:
English
Keywords:
Pubs id:
1151657
Local pid:
pubs:1151657
Deposit date:
2021-01-29

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