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Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein.

Abstract:

The tumor suppressor p14ARF is widely deregulated in many types of cancers and is believed to function as a failsafe mechanism, inhibiting proliferation and inducing apoptosis as cellular response to a high oncogene load. We have found that a 22-amino-acid-long peptide derived from the N-terminal part of p14ARF, denoted ARF(1-22), which has previously been shown to mimic the function of p14ARF, has cell-penetrating properties. This peptide is internalized to the same extent as the cell-penetr...

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Publisher copy:
10.1038/sj.mt.6300346

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Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
16
Issue:
1
Pages:
115-123
Publication date:
2008-01-01
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Source identifiers:
272859
Language:
English
Keywords:
Pubs id:
pubs:272859
UUID:
uuid:c78779f6-0e2c-4f77-90e4-1ba7ddce8756
Local pid:
pubs:272859
Deposit date:
2013-09-17

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