Journal article
Characterization of a novel cytotoxic cell-penetrating peptide derived from p14ARF protein.
- Abstract:
-
The tumor suppressor p14ARF is widely deregulated in many types of cancers and is believed to function as a failsafe mechanism, inhibiting proliferation and inducing apoptosis as cellular response to a high oncogene load. We have found that a 22-amino-acid-long peptide derived from the N-terminal part of p14ARF, denoted ARF(1-22), which has previously been shown to mimic the function of p14ARF, has cell-penetrating properties. This peptide is internalized to the same extent as the cell-penetr...
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- Publisher copy:
- 10.1038/sj.mt.6300346
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Bibliographic Details
- Journal:
- Molecular therapy : the journal of the American Society of Gene Therapy
- Volume:
- 16
- Issue:
- 1
- Pages:
- 115-123
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
-
1525-0024
- ISSN:
-
1525-0016
- Source identifiers:
-
272859
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:272859
- UUID:
-
uuid:c78779f6-0e2c-4f77-90e4-1ba7ddce8756
- Local pid:
- pubs:272859
- Deposit date:
- 2013-09-17
Terms of use
- Copyright date:
- 2008
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