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Journal article

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.

Abstract:

The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranu...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01754-06

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Journal:
Journal of virology
Volume:
81
Issue:
1
Pages:
434-438
Publication date:
2007-01-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:c7717a2c-2d51-46eb-bbe5-795e86c875b8
Source identifiers:
29495
Local pid:
pubs:29495

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