Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy.

Journal article

BACKGROUND: Eight decades ago, the ratio of monocytes to lymphocytes (hereafter, the "ML ratio") was noted to affect outcomes of mycobacterial infection in rabbits. Recent transcriptomic studies support a role for relative proportions of myeloid and lymphoid transcripts in tuberculosis outcomes. The ML ratio in peripheral blood is known to be governed by hematopoietic stem cells with distinct biases. METHODS: The predictive value of the baseline ML ratio was modeled in 2 prospective cohorts o...

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Authors: Naranbhai, V; Hill, A; Abdool Karim, S; Naidoo, K; Abdool Karim, Q

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 209
• Issue: 4
• Pages: 500-509
• Publication date: 2014-02-01
• DOI: 10.1093/infdis/jit494
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Disease-Free Survival; Incidence; Flow Cytometry; Drug Therapy, Combination; Risk Factors; Male; Young Adult; Kaplan-Meier Estimate; Tuberculosis; Cohort Studies; Female; Randomized Controlled Trials as Topic; Lymphocytes; Leukocyte Count; Humans; HIV Infections; Anti-Retroviral Agents; Monocytes; Proportional Hazards Models