IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.

Journal article

IL-4 has been implicated in the pathogenesis of a number of allergic inflammatory disease states where the accumulation of eosinophils is a prominent feature. The aim of the present study was to use an isotopic in vivo model to investigate the ability of recombinant rat IL-4 in inducing eosinophil accumulation in rat skin. 111In-eosinophil accumulation in response to intradermally injected IL-4 was measured during 0 to 4 h, 24 to 28 h, and 48 to 52 h. Accumulation was detected during the firs...

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Authors: Sanz, M; Marinova-Mutafchieva, L; Green, P; Lobb, R; Feldmann, M

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 160
• Issue: 11
• Pages: 5637-5645
• Publication date: 1998-06-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Receptors, Tumor Necrosis Factor; Antigens, CD18; Interleukin-4; Time Factors; Cell Movement; Eosinophils; Solubility; Antibodies, Monoclonal; Receptors, Tumor Necrosis Factor, Type I; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1; Recombinant Fusion Proteins; Immunoglobulin G; Intercellular Adhesion Molecule-1; Male; Cell Adhesion; Injections, Intradermal; Indium Radioisotopes; Integrin alpha4; Rats; Skin; Tumor Necrosis Factor-alpha; Animals; Antigens, CD; Dose-Response Relationship, Immunologic