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Modification of antigen impacts on memory quality after adenovirus vaccination.

Abstract:

The establishment of robust T cell memory is critical for the development of novel vaccines for infections and cancers. Classical memory generatedby CD8+ T cells is characterised by contracted populations homing to lymphoid organs. T cell “memory inflation”, as seen for example after cytomegalovirus infection, is the maintenance of expanded, functional, tissue-associated effector memory cell pools. Such memory pools may also be induced after adenovirus vaccination, and we recently defined com...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1502687

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
196
Issue:
8
Pages:
3354-3363
Publication date:
2016-03-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Pubs id:
pubs:609473
UUID:
uuid:c747de88-038a-4ee5-87c5-5deea6678ebe
Local pid:
pubs:609473
Source identifiers:
609473
Deposit date:
2016-03-24

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