Journal article
Comparison of antibody responses and parasite clearance in artemisinin therapeutic efficacy studies in Democratic Republic of Congo and Asia
- Abstract:
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Background
Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibodies confound parasite clearance measures. However, variation in naturally acquired antibodies across Asian and sub-Saharan African epidemiological contexts and their impact on parasite clearance re yet to be quantified.
Methods
In an artemisinin therapeutic efficacy study, antibodies to 12 pre-erythrocytic and erythrocytic P. falciparum antigens were measured in 118 children with uncomplicated P. falciparum malaria in the Democratic Republic of Congo (DRC) and compared with responses in patients from Asian sites, described elsewhere.
Results
Parasite clearance half-life was shorter in DRC patients (median, 2 hours) compared with most Asian sites (median, 2–7 hours), but P. falciparum antibody levels and seroprevalences were similar. There was no evidence for an association between antibody seropositivity and parasite clearance half-life (mean difference between seronegative and seropositive, −0.14 to +0.40 hour) in DRC patients.
Conclusions
In DRC, where artemisinin remains highly effective, the substantially shorter parasite clearance time compared with Asia was not explained by differences in the P. falciparum antibody responses studied.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 421.9KB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiac232
Authors
- Publisher:
- Oxford University Press
- Journal:
- The Journal of Infectious Diseases More from this journal
- Volume:
- 226
- Issue:
- 2
- Pages:
- 324–331
- Publication date:
- 2022-06-15
- Acceptance date:
- 2022-06-12
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pmid:
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35703955
- Language:
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English
- Keywords:
- Pubs id:
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1264087
- Local pid:
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pubs:1264087
- Deposit date:
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2022-07-20
- ARK identifier:
Terms of use
- Copyright holder:
- Cutts et al.
- Copyright date:
- 2022
- Rights statement:
- ©2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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