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Functional identification of the Plasmodium centromere and generation of a Plasmodium artificial chromosome.

Abstract:

The artificial chromosome represents a useful tool for gene transfer, both as cloning vectors and in chromosome biology research. To generate a Plasmodium artificial chromosome (PAC), we had to first functionally identify and characterize the parasite's centromere. A putative centromere (pbcen5) was cloned from chromosome 5 of the rodent parasite P. berghei based on a Plasmodium gene-synteny map. Plasmids containing pbcen5 were stably maintained in parasites during a blood-stage infection wit...

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Publication status:
Published

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Publisher copy:
10.1016/j.chom.2010.02.010

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Journal:
Cell host and microbe
Volume:
7
Issue:
3
Pages:
245-255
Publication date:
2010-03-05
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
URN:
uuid:c73a9f69-0a9e-4569-8349-70db078cc184
Source identifiers:
94895
Local pid:
pubs:94895

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