Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.

Journal article

OBJECTIVE: High titers of specific anti-citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well-defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their rel...

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Authors: Snir, O; Widhe, M; Hermansson, M; von Spee, C; Lindberg, J

• Journal: Arthritis and rheumatism
• Volume: 62
• Issue: 1
• Pages: 44-52
• Publication date: 2010-01-01
• DOI: 10.1002/art.25036
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Mutation; Phosphopyruvate Hydratase; Synovial Fluid; Young Adult; Arthritis, Rheumatoid; Citrulline; Middle Aged; Aged; HLA-DRB1 Chains; Female; Genotype; DNA-Binding Proteins; Tumor Markers, Biological; Aged, 80 and over; HLA-DR Antigens; Tumor Suppressor Proteins; Collagen Type II; Humans; Fibrinogen; Adult; Autoantigens; Enzyme-Linked Immunosorbent Assay; Male; Autoantibodies; Vimentin; Peptides, Cyclic