Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against influenza A M2 protein.

Journal article

Influenza virus infection is a prevalent disease in humans. Antibodies against hemagglutinin have been shown to prevent infection and hence hemagglutinin is the major constituent of current vaccines. Antibodies directed against the highly conserved extracellular domain of M2 have also been shown to mediate protection against Influenza A infection in various animal models. Active vaccination is generally considered the best approach to combat viral diseases. However, passive immunization is an...

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Authors: Beerli, R; Bauer, M; Schmitz, N; Buser, R; Gwerder, M

• Publication status: Published
• Journal: Virology journal
• Volume: 6
• Issue: 1
• Pages: 224
• Publication date: 2009-01-01
• DOI: 10.1186/1743-422x-6-224
• EISSN: 1743-422X
• ISSN: 1743-422X
• Language: English
• Keywords: Antibody Specificity; Cell Line; Disease Models, Animal; Cricetinae; Orthomyxoviridae Infections; Viral Matrix Proteins; Humans; Mice; Influenza A Virus, H1N1 Subtype; Amino Acid Sequence; Animals; Female; Treatment Outcome; Mice, Inbred C57BL; Influenza A Virus, H5N1 Subtype; Immunization, Passive; Influenza Vaccines; Antibodies, Monoclonal; Molecular Sequence Data