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Relapse of depression after rapid depletion of tryptophan.

Abstract:

BACKGROUND: Major depression is a common disorder but the pathophysiology is poorly understood. Current hypotheses implicate deficient function of brain serotonin pathways because drugs that selectively increase brain serotonin activity are effective antidepressants. However, there is no direct evidence that lowered serotonin function causes major depression. We aimed to assess whether lowering of brain serotonin activity by depletion of its amino acid precursor, tryptophan, could provoke a s...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Lancet
Volume:
349
Issue:
9056
Pages:
915-919
Publication date:
1997-03-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:c70008bd-e51c-4223-81f2-59e24e6af3ff
Source identifiers:
186054
Local pid:
pubs:186054

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