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Journal article

Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons

Abstract:

Many basal ganglia neurodevelopmental disorders are thought to result from imbalances in the activity of the D1‐expressing direct‐pathway and D2‐expressing indirect‐pathway striatal projection neurons (SPNs). Insight into these disorders is reliant on our understanding of normal D1 and D2 SPN development. Here we provide the first detailed study and quantification of the striatal cellular and circuit changes occurring for both D1 and D2 SPNs in the first postnatal weeks using in vitro whole‐c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1113/jp278416

Authors


Krajeski, RN More by this author
Macey‐Dare, A More by this author
Heusden, F More by this author
Ebrahimjee, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
ORCID:
0000-0001-9787-3307
Publisher:
Wiley Publisher's website
Journal:
The Journal of Physiology Journal website
Volume:
597
Issue:
21
Pages:
5265-5293
Publication date:
2019-09-18
Acceptance date:
2019-09-04
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pubs id:
pubs:1055444
URN:
uri:c6fd1a50-d5fc-4466-be8b-1ee75afcafc6
UUID:
uuid:c6fd1a50-d5fc-4466-be8b-1ee75afcafc6
Local pid:
pubs:1055444

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