Journal article
Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches
- Abstract:
- Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2021.631279
- Publication website:
- https://archiv.ub.uni-heidelberg.de/volltextserver/37208/1/RTG2099_FinalReport.pdf
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 12
- Pages:
- 631279-631279
- Article number:
- 631279
- Publication date:
- 2021-03-15
- DOI:
- EISSN:
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1664-3224
- ISSN:
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1664-3224
- Language:
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English
- Keywords:
- Pubs id:
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1172022
- Local pid:
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pubs:1172022
- Source identifiers:
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W3136484732
- Deposit date:
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2026-03-24
- ARK identifier:
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Terms of use
- Copyright date:
- 2021
- Licence:
- CC Attribution (CC BY)
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