Journal article
Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells
- Abstract:
- The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 904.3KB, Terms of use)
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- Publisher copy:
- 10.1016/j.jtbi.2018.10.040
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of Theoretical Biology More from this journal
- Volume:
- 461
- Pages:
- 239-253
- Publication date:
- 2018-10-23
- Acceptance date:
- 2018-10-19
- DOI:
- EISSN:
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1095-8541
- ISSN:
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0022-5193
- Pmid:
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30359573
- Language:
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English
- Keywords:
- Pubs id:
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pubs:935890
- UUID:
-
uuid:c6e13b7f-10a1-4cb8-a103-f5c7959f8497
- Local pid:
-
pubs:935890
- Source identifiers:
-
935890
- Deposit date:
-
2018-11-16
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2018
- Notes:
- © 2018 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.jtbi.2018.10.040
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